Intestinal microbiota plays a key role in human health,  Disruption of the epithelium provokes activation of local and systemic immune system, leading to a variety of inflammatory, metabolic and neuro-degenerative pathologies. Probiotics and prebiotics are extensively developed to aid maintaining and repairing the impaired balance between intestinal microbiota and host immune response. Their selection and validation is a complex process. Ilia Belotserkovsky explores ex-vivo experimental approaches involving both human fecal microbiota and primary immune cells separated by intestinal epithelial barrier for pre- and probiotics evaluation.

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